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CRISPR Gene Editing 211Ʊ
October 16, 2020

Top Headlines
 

This year's Nobel Prize in Chemistry is being awarded to Emmanuelle Charpentier and Jennifer A. Doudna for the development of the CRISPR/Cas9 method for ...

CRISPRing Trees for a Climate-Friendly Economy

Researchers have discovered a way to stably fine-tune the amount of lignin in poplar by applying CRISPR/Cas9 technology. Lignin is one of the main structural substances in plants and it makes ...

Something Old, Something New Combine for Effective Vaccine Against Parasitic Skin Disease

Scientists are planning for Phase 1 human trials of a vaccine they developed by using CRISPR gene-editing technology to mutate the parasite that ...

Biologists Create New Genetic Systems to Neutralize Gene Drives

Addressing concerns about gene drive releases in the wild, scientists have developed two new genetic systems that halt or eliminate gene drives after release. Created in fruit flies, the e-CHACRs and ...
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Earlier Headlines
 

Quality Control Mechanism Closes the Protein Production 'on-Ramps'

Recent work revealed a newfound quality control system in the protein production assembly line with possible implications for understanding neurogenerative ...

New CRISPR C-to-G DNA Base Editor Expands the Landscape of Precision Genome Editing

The new base editing platform may help researchers understand and correct genetic diseases by selective editing of single DNA 'letters' across nucleobase ...

Site-Directed Mutagenesis in Wheat Via Haploid Induction by Maize

Site-directed mutagenesis facilitates the experimental validation of gene function and can speed up plant breeding by producing new biodiversity or by reproducing previously known gene variants in ...

Megaphages Harbor Mini-Cas Proteins Ideal for Gene Editing

Cas proteins like CRISPR-Cas9 have great potential for gene therapy to treat human disease and for altering crop genes, but the gene-targeting and gene-cutting Cas proteins are often large and hard ...

Safer CRISPR Gene Editing With Fewer Off-Target Hits

The CRISPR system is a powerful tool for the targeted editing of genomes, with significant therapeutic potential, but runs the risk of inappropriately editing ''off-target'' ...

Comparing 13 Different CRISPR-Cas9 DNA Scissors

Scientists have achieved the most extensive high-throughput analysis of CRISPR-Cas9 activities. The team developed deep-learning-based computational models that predict the activities of SpCas9 ...

Light-Activated 'CRISPR' Triggers Precision Gene Editing and Super-Fast DNA Repair

In a series of experiments using human cancer cell lines, scientists say they have successfully used light as a trigger to make precise cuts in genomic material rapidly, using a molecular scalpel ...

Scientists Aim Gene-Targeting Breakthrough Against COVID-19

Scientists at Berkeley Lab's Molecular Foundry have joined forces with a research team at Stanford to aim a gene-targeting, antiviral agent called PAC-MAN against ...

Gene Found That Causes Eyes to Wither in Cavefish

In a new study led by University of Maryland researchers, scientists discovered a gene that prevents blood flow to blind cavefish eyes during development. It is the same gene responsible for ...

Key Player in Hepatitis A Virus Infection

Researchers designed experiments using gene-editing tools to discover how molecules called gangliosides serve as de facto gatekeepers to allow the virus entry into liver cells and trigger ...

Exchange of Arms Between Chromosomes Using Molecular Scissors

The CRISPR/Cas molecular scissors work like a fine surgical instrument and can be used to modify genetic information in plants. Research teams have now not only exchanged single genes, but recombined ...

Directed Protein Evolution With CRISPR-Cas9

New area of application for gene scissors: Optimized proteins for biomedical ...

CRISPR a Tool for Conservation, Not Just Gene Editing

The gene-editing technology CRISPR has been used for a variety of agricultural and public health purposes -- from growing disease-resistant crops to, more recently, a diagnostic test for the virus ...

Researchers Are Making Recombinant-Protein Drugs Cheaper

The mammalian cell lines that are engineered to produce high-value recombinant-protein drugs also produce unwanted proteins that push up the overall cost to manufacture these drugs. These same ...

Gene-Editing Protocol for Whitefly Pest Opens Door to Control

Whiteflies are among the most important agricultural pests in the world, yet they have been difficult to genetically manipulate and control, in part, because of their small size. An international ...

Diabetes Reversed in Mice With Genetically Edited Stem Cells Derived from Patients

Researchers have used induced pluripotent stem cells produced from the skin of a patient with a rare, genetic form of insulin-dependent diabetes, transformed the stem cells into insulin-producing ...

Genetic Variation Not an Obstacle to Gene Drive Strategy to Control Mosquitoes

New research from entomologists clears a potential obstacle to using CRISPR-Cas9 'gene drive' technology to control mosquito-borne diseases such as malaria, dengue fever, yellow fever and ...

How Cells Recognize Uninvited Guests

Until now, the immune sensor TLR8 has remained in the shadows of science. A research team has now discovered how this sensor plays an important role in defending human cells against intruders. The ...

Moving Closer to Producing Heparin in the Lab

Researchers moved one step closer to the ability to make heparin in cultured cells. Heparin is a potent anti-coagulant and the most prescribed drug in hospitals, yet cell-culture-based production of ...

Research Breakthrough: Humans Are Not the First to Repurpose CRISPR

We humans are far from the first to exploit the benefits of CRISPR. Groundbreaking research has helped to redefine what CRISPR is. Researchers have discovered that primitive bacterial parasites ...

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